Figure 2.
RACev enhanced endothelial cell proliferation in a dose-dependent manner. (A,B) 5 *105 RACs-derived EVs (500K) increased the cell numbers and (B,C) growth area in culture dishes. (D) The miRs responsible for proliferation and anti-apoptosis were markedly upregulated in RACev vs. MSCev. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001 for RACev-500K vs. other groups. Statistical significance was determined using one way ANOVA followed by Tukey's multiple comparison test. The results are presented as mean ± SEM (n = 7–10 per group).