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. 2021 Oct 20;8:754254. doi: 10.3389/fcvm.2021.754254

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Copyright © 2021 Salybekov, Salybekova, Sheng, Shinozaki, Yokoyama, Kobayashi and Asahara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RACev derived angiomiRs enhanced angiogenesis in infarcted tissues. (A,B) Microvascular density was enhanced in myocardial infarcted tissue in RACev transplanted group. Cardiac capillaries were stained with FITC conjugated Isolectin B4 (green) (C) Mechanistically, enhanced capillary formation in injured myocardium may couple with well-known angiomiRs (miR-126-3p and 5p, miR-195-5p, etc.) delivery by RACev. Scale bar = 50μm. *P < 0.05; **P < 0.01; ***P < 0.001 vs. MSCev group; Statistical significance was determined using Kruskal-Wallis followed by Dunn's multiple comparisons post-hoc test. Results are presented as the mean ± SEM (n = 8–10 per group).