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Schematic of the mechanism by which microtubule stabilization potentiates chondrogenic differentiation of synovial mesenchymal stem cells. By inhibiting Yes-associated protein (YAP) expression and activity, stabilized microtubule (MT) activated the chondrogenesis. MT stabilization repressed primary cilia formation, inhibited the Indian hedgehog (IHH) signal, and promoted chondrogenic differentiation of SMSCs.
