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. 2021 Oct 20;8:740472. doi: 10.3389/fvets.2021.740472

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Copyright © 2021 Li, Liu, Qiu, Liao, Peng, Chen and Shu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Positions of identified signatures in structural and functional domains of HA (A), NP (B), and NA (C) proteins. The positions and dominant amino acid residues of Avian→ Canine (H3N2) signatures are placed below the pale-yellow bar. Black star: Avian→ Canine (H3N2), blue circle: Equine→ Canine (H3N8), brown hexagon: Avian→ Equine (H3N8), red triangle: Avian→ Human (H3N2), green square: Avian→ Swine (H3N2), and purple triangle rhomb: Swine→ Human (H3N2). The detail of these signatures are in Table 2.