FIGURE 1.

Efficient RA signaling robustness following transient physiological manipulation of RA levels. (A) Schematic depiction of the experimental design to directly challenge and study the robustness of RA signaling during embryogenesis. Timing and developmental stages are shown. (B) Principal Components 1 and 2 (PC1, PC2) of all six biological replicates studied by time series RNAseq. (C) Heatmap of gene expression of the top-100 positive and top-100 negative loadings corresponding to PC1 and PC2. A subset of the genes is highlighted based on the relevance to early developmental processes.