FIGURE 9.

Proposed model of the alternative regulatory schemes to achieve RA robustness. Schematic representation of two alternative scenarios in the decision tree to achieve robustness. These two scenarios are representative of the multiple permutations possible to achieve similar robustness outcomes. Each clutch follows a decision trajectory based on the direction of RA fluctuation and clutch-specific composition of RA network variants. In this scheme, uneven robustness arises when the regulatory feedback response of a clutch is optimized for one scenario over another. Our results revealed such a trade-off over distinct objectives of counteracting RA increase versus decrease.