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. 2021 Oct 20;9:763060. doi: 10.3389/fped.2021.763060

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Copyright © 2021 Aldersley, Lawrenson, Human, Shaboodien, Cupido, Comitis, De Decker, Fourie, Swanson, Joachim, Magadla, Ngoepe, Swanson, Revell, Ramesar, Brooks, Saacks, De Koning, Sliwa, Anthony, Osman, Keavney and Zühlke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PROTEA recruitment: Inclusion and exclusion criteria, participating centers, and recruitment to aims 1–3. GSH, Groote Schuur Hospital; RCWMCH, Red Cross War Memorial Children's Hospital; TBH, Tygerberg Hospital; HCC, Health Care Centre; CNV, Copy Number Variant analysis; GUCH, Grown-Up Congenital Heart; PDA, patent ductus arteriosus; PFO, patent foramen ovale; PPS, peripheral pulmonary stenosis; RF, Risk Factor; SES, Socio-economic status; TOF, tetralogy of Fallot; WES, Whole Exome Sequencing.