Table 1.
PROTEA CHD-subtype pediatrica cohort-prevalence compared with the global prevalence studies by Liu et al. (8) and van der Linde et al. (4).
| PROTEA | Liu et al. (8) | van der Linde et al. (4) | |||||
|---|---|---|---|---|---|---|---|
| (N = 1,597) | (N = 1,161,030) | (N = 164,396) | |||||
| CHD Subtype | No. (%) | No. (%) | PR (95%CI) | p | No. (%) | PR (95%CI) | p |
| Ventricular septal defect (Q21.0) | 322 (20) | 412,955 (36) | 0.57 (0.51:0.63) | p < 0.001 | 55,895 (34) | 0.59 (0.54:0.65) | p < 0.001 |
| Patent ductus arteriosus (Q25.0) | 182 (11) | 118,100 (10) | 1.12 (0.98:1.28) | p = 0.11 | 16,440 (10) | 1.14 (0.99:1.31) | p = 0.064 |
| Atrial septal defect (Q21.1) | 179 (11) | 178,543 (15) | 0.73 (0.63:0.84) | p < 0.001 | 21,371 (13) | 0.86 (0.75:0.99) | p = 0.034 |
| Atrioventricular septal defect (Q21.2) | 119 (7) | 41,739 (4) | 2.07 (1.74:2.46) | p < 0.001 | NR (≤4) b | - | - |
| Pulmonary stenosis (Q22.1) | 84 (5) | 72,367 (6) | 0.84 (0.69:1.04) | p = 0.11 | 13,152 (8) | 0.66 (0.53:0.81) | p < 0.001 |
| Tetralogy of Fallot (Q21.3) | 80 (5) | 51,341 (4) | 1.13 (0.91:1.4) | p = 0.25 | 8,220 (5) | 1 (0.81:1.24) | p = 0.99 |
| Coarctation of the aorta (Q25.1) | 46 (3) | 41,449 (4) | 0.81 (0.61:1.07) | p = 0.14 | 8,220 (5) | 0.58 (0.43:0.77) | p < 0.001 |
| Pulmonary atresia (Q22.0) | 44 (3) | 15,186 (1) | 2.11 (1.57:2.82) | p < 0.001 | NR | - | - |
| Aortic regurgitation (Q23.1) | 43 (3) | 26,913 (2) | 1.16 (0.86:1.56) | p = 0.32 | NR | - | - |
| Double outlet right ventricle (Q20.2) | 40 (3) | 15,128 (1) | 1.92 (1.41:2.61) | p < 0.001 | NR | - | - |
| Transposition of the great arteries (Q20.3) | 39 (2) | 44,340 (4) | 0.64 (0.47:0.87) | p = 0.004 | 8,220 (5) | 0.49 (0.36:0.67) | p < 0.001 |
| Tricuspid atresia or stenosis (Q22.4) | 17 (1) | 12,435 (1) | 0.99 (0.62:1.6) | p = 0.98 | NR | - | - |
| TAPVR (Q26.2) | 14 (1) | 17,427 (2) | 0.58 (0.35:0.98) | p = 0.04 | NR | - | - |
| Aortic stenosis (Q23.0) | 12 (1) | 27,098 (2) | 0.32 (0.18:0.57) | p < 0.001 | 6,576 (4) | 0.19 (0.11:0.33) | p < 0.001 |
Significant differences between CHD subtype cohort-prevalence are highlighted in bold and in pink where the PROTEA cohort-prevalence is lower or in green where it is higher. See Supplementary Table 2 for all results.
a
The data represents the PROTEA pediatric cohort only.
b
Atrioventricular septal defect data is not presented in van der Linde et al. (4), results are inferred from lowest presented proportion (Aortic Stenosis 4%). PR, prevalence ratio; NR, Not reported; TAPVR, Total anomalous pulmonary venous return.