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. 2021 Oct 20;12:721426. doi: 10.3389/fmicb.2021.721426

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Copyright © 2021 Cai, Zheng, Lu, Zhao, Sun, Tang, Xiao, Wang, Tong, Zhao, Xiao, Zhao and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The induced β-lactam resistance of S. sciuri caused by the thickened cell wall. (A) KEGG enrichment scatter map of the upregulated differentially expressed gene in NWAF26^R compared with NWAF26. (B) The expression of genes related to wall teichoic acid (WTA) synthesis pathway was upregulated in NWAF26^R and highlighted with red color, the number represented the fold changes of upregulation. (C) Transmission electron microscopy (TEM) analysis of NWAF26 and its derivations at the stationary phase. NWAF26^R-R10 represents the 10th generation isolate induced from NWAF26^R without oxacillin. The standard ruler is 100 nm.