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. 2021 Oct 20;12:749935. doi: 10.3389/fmicb.2021.749935

FIGURE 2.

FIGURE 2

Maximum likelihood core-SNP phylogeny of 49 Australian and New Zealand daptomycin-resistant E. faecium isolates. Coloured blocks show the multi-locus sequence type (MLST), country of origin (country), year of isolation (year), van status (i.e., vanA, vanB, and VSE) and daptomycin MIC (8 and 16 mg/L) for each isolate within the phylogeny. Grey blocks show the presence of the RNAP β-subunit S494F mutation (RpoB S494F), the RNAP β′-subunit T641K mutation (RpoC T641K), the LiaR S19F mutation, the DltC S63C mutation, the LiaR W73C and LiaS T120A co-occurring mutations or mutations within ClsA previously associated with daptomycin resistance in VREfm (ClsA various). The vanA-VREfm strain D0 (TX16) (Diaz et al., 2014) was used as the reference.