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. 2021 Oct 20;12:749935. doi: 10.3389/fmicb.2021.749935

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Copyright © 2021 Li, Higgs, Turner, Nong, Gorrie, Sherry, Dyet, Seemann, Williamson, Stinear, Howden and Carter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of daptomycin treatment in a mouse model of VREfm bacteraemia. VREfm blood counts in uninfected mice administered sterile rate faecal extract (SRFE) or in mice infected with the daptomycin-susceptible isolate DMG1800332 (green) or daptomycin-resistant isolates DMG1901766 (orange), DMG1700661 (blue), or DMG1700787 (purple), and treated with either saline (untreated) or 50 mg/kg of daptomycin (DAP treated). Each coloured circle represents one animal (n = 10–15 mice), with the median value displayed by the horizontal black line. Error bars represent the 95% CI. p-Values were calculated using a Mann–Whitney non-parametric test and are shown for the indicated groups; ns indicates no significant difference between groups (p ≥ 0.05).