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. 2021 Oct 20;12:760017. doi: 10.3389/fmicb.2021.760017

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Copyright © 2021 Qi, Angermayr and Bollenbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The suppressive effect of ERY on TMP requires the presence of the crl gene in BW25113. Isoboles for TMP + ERY drug combinations for the E. coli BW25113/pUA66 and BW25113 Δcrl strains. Whereas ERY exerts a strong suppressive effect on TMP when tested against the BW25113/pUA66 strain which has an intact crl gene (A), the suppression is removed when tested against the BW25113 Δcrl strain (B).