TABLE 1.

Sample groups TMP, ERY, TMP + ERY and the no-antibiotic treatment control for RNA-Seq transcriptomic profiling using the E. coli MG1655 strain.

Sample group	Description
No-antibiotic control	Control group without antibiotic treatment
TMP	Trimethoprim-treatment resulting in 50% reduction in exponential growth rate (IC50); concentration of TMP = 0.0625 μg/mL
ERY	Erythromycin-treatment resulting in 50% reduction in exponential growth rate (IC50); concentration of ERY = 42 μg/mL
TMP + ERY	Combination treatment with trimethoprim and erythromycin, both of which were used at their respective IC50 concentrations
TMP (0.2 × IC50) + ERY (0.6 × IC50)	Combination treatment with trimethoprim and erythromycin that resulted in approximately 50% reduction in exponential growth rate relative to the no-antibiotic control group