Figure 1.

Associations between E354 (rs1800437) and cardiometabolic disease end points, glycemic traits, cardiovascular risk factors and lipids, anthropometric traits, and biomarkers estimated with 2SMR. A: Associations with cardiometabolic disease end points are shown in blue and are represented as ORs (95% CI) for each disease per copy of rs1800437. B: Associations with glycemic traits are shown in orange and cardiovascular and lipid traits in green, and anthropometric traits and biomarkers are shown in yellow and purple, respectively. Estimates are represented as β (95% CI) for each outcome per copy of rs1800437. All traits are in SD units aside from fasting and 2-h glucose, which are in mmol/L; fasting insulin, in log (pmol/L); and HbA_1c, in mmol/mol. Fold change insulin represents the fold change in insulin levels between fasting and 2-h measures. A Bonferroni significance threshold of P ≤ 0.001 was used, accounting for the number of traits tested. *HbA_1c estimates are in SD units per copy of E354. The corresponding clinical units, % (mmol/mol), are as follows: −2.15% (95% CI −2.15, −2.14) and −0.07 mmol/mol (95% CI −0.07, −0.06). adj., adjustment.