Table 2.

Independent CAD variants identified using approximate conditional analysis

Variant*	Chr: pos	Closest gene	EA	EAF	Marginal β (SE)†	Marginal P†	Conditional β (SE)‡	Conditional P‡	N	R2 with rs1800437
rs429358	19: 45411941	APOE	T	0.85	−0.09 (0.008)	2.86 × 10−27	−0.08 (0.008)	5.87 × 10−23	286,423	0.001
rs7412	19: 45412079	APOE	T	0.08	−0.14 (0.011)	1.66 × 10−35	−0.12 (0.011)	1.58 × 10−28	275,803	0.004
rs11673093	19: 45742094	EXOC3L2	A	0.26	0.04 (0.007)	4.11 × 10−11	0.04 (0.007)	3.09 × 10−10	300,789	0
rs1964272	19: 46190268	SNRPD2	A	0.48	−0.03 (0.006)	9.65 × 10−9	−0.03 (0.006)	1.87 × 10−7	299,519	0.27

Chr, chromosome; EA, effect allele; EAF, effect allele frequency; pos, position; N, number of participants; R², LD estimate.

^*The independent CAD variants in the 1-Mb region on either side of E354 are shown.

^†Log ORs from the original GWAS summary statistics.

^‡Log ORs from the joint model fitted by GCTA.