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. 2021 Aug 11;70(11):2476–2491. doi: 10.2337/db20-1228

Figure 3.

Figure 3

Hepatocellular eNOS deficiency reduces hepatic mitochondrial function. In eNOSfl/fl and eNOShep−/− mice on either a CD or WD for 16 weeks. A: Isolated liver mitochondria complete, incomplete, and total [1-14C] palmitate oxidation to CO2 (n = 13–17/group). B: Whole-liver complete, incomplete, and total [1-14C] palmitate oxidation to CO2 (n = 13–17/group). C: Oxygen consumption in isolated liver mitochondria (n = 6–10/group). D: PCoA stimulated H2O2 emission in isolated liver mitochondria from male and female (combined) eNOSfl/fl and eNOShep−/− fed a CD only (n = 7–9/group). Data are presented as mean ± SD. *Main effect of diet (P < 0.05 vs. CD). #Main effect of genotype (P < 0.05 vs. eNOSfl/fl). ASMs, acid-soluble metabolites; CD, control diet; OCR, oxygen consumption rate; PCoA, palmitoyl-CoA; WD, Western diet.