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. 2021 Aug 30;70(11):2580–2594. doi: 10.2337/db21-0422

Figure 4.

Figure 4

Proinsulin and insulin double immunofluorescence showing random blood glucose (BG) at the time of euthanasia. A: WT control. B: Ins2-proinsulin-R(B22)E heterozygote (Het) (6-week-old female). C: Normoglycemic 4-week-old female Ins2-proinsulin-R(B22)E homozygote (Hom). D and E: Ins2-proinsulin-R(B22)E-Hom 7-week-old female. F: Quantitation of insulin-positive cytoplasmic area as a percentage of total β-cell cytoplasmic area in independent islets from the genotypes indicated (mean ± SD; P = 0.0002). ***P < 0.001.