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Growing subpopulations of proinsulin-enriched cells (red) and glucagon-enriched cells (blue) and a decline of insulin-enriched cells (green) in Ins2-proinsulin-R(B22)E heterozygotes (Het) and homozygotes (Hom), as identified by triple immunofluorescence. Random blood glucose levels are indicated. A: WT 6-week-old female. B and C: Ins2-proinsulin-R(B22)E-Het females (age 6.5 weeks). D and E: Ins2-proinsulin-R(B22)E-Hom females (ages 4 and 6 weeks, respectively). Proins, proinsulin.
