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. 2021 Sep 15;70(11):2518–2531. doi: 10.2337/db21-0398

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© 2021 by the American Diabetes Association

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Molidustat increases HIF signaling in human cardiomyocytes. Hypoxia-inducible factor (HIF)1α protein levels in control and molidustat-treated (Moli) IMR90 hiPSC-CM (A). Expression of HIF1α target genes in control and molidustat-treated cardiomyocytes, including GLUT1, aldolase A, enolase 1, phosphoglycerate kinase 1 (PGK1), bcl2/adenovirus E1B 19kDa–interacting protein 3 (BNIP3), prolyl hydroxylase domain (PHD)2, factor inhibiting HIF (FIH), and HIF1α mRNA (B–E and H–K). F and G: Glucose consumption by and lactate release from control and molidustat-treated cardiomyocytes. *P < 0.05 vs. control. a.u, arbitrary units.