Figure 3.

Molidustat increases systemic HIF targets in T2D. Hemoglobin content, body weight, heart weight, and epididymal fat pad weight in control and diabetic rats, with and without molidustat treatment (A–D). Hepatic triglycerides and fed blood glucose concentrations in control and diabetic rats, with and without molidustat treatment (E and F). Cardiac VEGF expression and lactate dehydrogenase (LDH) protein levels in control and diabetic rats, with and without molidustat treatment (G and H). *P < 0.05 vs. respective control group; #P < 0.05 vs. diabetic untreated; γP < 0.05 significant interaction between disease and drug treatment. a.u, arbitrary units.