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. 2021 Sep 15;70(11):2518–2531. doi: 10.2337/db21-0398

Figure 4.

Figure 4

Molidustat increases cardiac glucose metabolism in T2D. Cardiac glycolytic rates and lactate efflux rates in control and diabetic rats, with and without molidustat treatment (A and B). GLUT1 and GLUT4 protein levels in control and diabetic rats, with and without molidustat treatment (C and D). Sarcolemmal GLUT1 and GLUT4 protein levels in control and diabetic rats, with and without molidustat treatment (E and F). State 3 ADP-stimulated and maximally FCCP-stimulated pyruvate respiration rates in isolated mitochondria from control and diabetic rats, with and without molidustat treatment (G and H). *P < 0.05 vs. control, #P < 0.05 vs. diabetic untreated, †P < 0.05 significant effect of molidustat treatment at two-way ANOVA. a.u, arbitrary units.