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. 2021 Sep 8;8(21):2100460. doi: 10.1002/advs.202100460

Figure 1.

Figure 1

Genetic‐engineering biosynthetic cellular membrane vesicles (Bio‐MVs) with NGR tripeptide (Asn‐Gly‐Arg) displaying for oncolytic adenovirus (OA) delivery. A) Schematic illustration for the synthetic process. B) Western blotting analysis to detect the NGR peptide and marker protein Alix on the Bio‐MVs. C) Transmission electron microscopy (TEM) images of purified OA@Bio‐MVs which were negatively stained with uranyl acetate. Scale bar: 100 nm. D) Fluorescence images of different tissues and organs after injected with OA and NGR‐MVs@OA. E) Tumor growth curves and body weight of tumor bearing nude mice after various kinds of OA treatments. Reproduced with permission.[ 52 ] Copyright 2019, American Chemical Society.