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. 2021 Sep 8;8(21):2100460. doi: 10.1002/advs.202100460

Figure 2.

Figure 2

Genetically engineered Bio‐MVs with virus epitope displaying for immune protection. A) The location of recombinant protein in HeLa and HEK 293T cells with the strategy of de novo construction of recombinant membrane proteins (rMPs). B) The cryo‐EM images of purified Bio‐MVs that were incubated with different concentrations of chemical surfactants. Scale bar: 100 nm. C) Co‐IP and western blotting analysis confirmed the presence of virus epitope on the exterior of Bio‐MVs. D) Serum anti‐L2 epitope antibody titer was determined by ELISA after the mice immunized. Reproduced with permission.[ 7 ] Copyright 2015, National Academy of Sciences.