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. 2021 Sep 8;8(21):2100460. doi: 10.1002/advs.202100460

Figure 5.

Figure 5

Schematic illustration and characterization of PD‐1 blockade cellular Bio‐MVs for cancer immunotherapy. A) Schematic illustration shows the preparation of PD‐1 Bio‐MVs loaded with 1‐MT. B,C) Schematic illustration shows PD‐L1 blockade by PD‐1 Bio‐MVs could revert the exhausted CD8+ T cells to attack tumor cells. Reproduced with permission.[ 42c ] Copyright 2018, Wiley‐VCH. D) The L8057 cell line with murine PD‐1 stably expressing and production of platelets. E) The PD‐1 expressed on the platelets can specifically concentrate on the surgery wound. F) PD‐L1 blockade by PD‐1 expressing platelets revert exhausted CD8+ T cells for tumor cell eradication. Reproduced with permission.[ 96 ] Copyright 2018, American Chemical Society.