Figure 3.

Identification of UM molecular subgroups using individual CNAexp and METexp genes for single clustering and mRNA + CNAexp + METexp for joint clustering. (A, D) AUC values obtained for each value of k. The optimal k has the highest AUC value, in which (A—left, A–right, and D) the results are of CNAexp alone, METexp alone, and integration of mRNA + CNAexp + METexp, respectively. (B) Overlap test between subgroups of CNAexp and METexp. (E) Overlap test between integrative subgroups versus CNAexp subgroups (left) and versus METexp subgroups (right). (C, F) Kaplan–Meier survival curves for the CNAexp subgroups (C—left), METexp subgroups (C—right), and (F) integrated subgroups.