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. 2021 Oct 20;11:744724. doi: 10.3389/fonc.2021.744724

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Copyright © 2021 Jain, Khorrami, Gupta, Rajiah, Bera, Viswanathan, Fu, Dowlati and Madabhushi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Segmented tumor regions and heatmap of intratumoral Haralick (entropy) feature in the pretreatment CT scans for representative non-responder and responder patients. (B) Segmented tumor regions and heatmap of peritumoral Gabor feature in the pretreatment CT scans for representative non-responder and responder patients. The middle column is a magnified view of tumor anatomy in both Figures 5A, B , and the right column is a color heatmap. (C) Box-and-whisker plots for four features that best distinguish chemotherapy response.