Figure 2.

(A) bona fide network analysis of HCoV-host interactome network. A subnetwork illustrating the HCoV-host interactome where colored nodes represent diverse enriched pathways in host proteins and edge colors represent evidence collected from protein-protein interactions. The Figure was generated using Cytoscape (111) with the host proteins shown to be interacting with the viral conglomerate proteins. The pink edges indicate the experimentally validated interactions, with green, grey, orange, and maroon edges representing fusion, subcellular location, coexpression and associations from text mining. (B) A sub-figure with all the viral proteins in yellow colored nodes and the host proteins in blue colored nodes. This figure is depicted keeping in view of the interplay of various host-pathogen interactions. A Supplementary Table 1 is added which shows the list of interactants based on the text mining, co-expression network and overall scores. However, as no co-expression network studies have been deciphered yet between virus and the host, the network is distributed largely based on the text mining interactions. In conclusion, the network largely explores how the SARS-CoV-2 proteins have an interplay with a lot of host proteins, viz. SPECC1, a mitochondrial like protein, PHB, a prohibitin associated with cancer and FGL2/fibroleukin prothrombinase, a protein associated with clotting factors and alveolar macrophage activation.