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Cross-reactive T cell response. C57BL/6 mice were immunized with indicated peptides and an IFN-γ EliSpot assay was performed re-stimulating ex vivo splenocytes with the indicated challenging peptides. (A) Absolute immune responses elicited by wild type and heteroclitic peptides. (B) Percentage of T cell response compared to the one observed by re-stimulation with the same peptide used in the immunization (= 100).
