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. 2021 Oct 20;12:769799. doi: 10.3389/fimmu.2021.769799

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Copyright © 2021 Tagliamonte, Mauriello, Cavalluzzo, Ragone, Manolio, Luciano, Barbieri, Palma, Scognamiglio, Di Mauro, Di Bonito, Tornesello, Buonaguro, Vitagliano, Caporale, Ruvo and Buonaguro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune correlates in the therapeutic experimental model. Spleens (A) and TILs (B) from sacrificed animals in each HPV-E7 immunization groups were evaluated in an IFNγ EliSpot assay after re-challenge with wt epitope. (C) Cytotoxicity assay was assessed using TC1 cells as target cells at the indicated target:effector (T:E) ratios. Each peptide immunization was performed with the MCT + ICI combination.