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. 2021 Oct 20;12:733231. doi: 10.3389/fimmu.2021.733231

Figure 2.

Figure 2

Generating a unique tolDC transcriptome. (A) Principal component analysis (PCA) plot characterizing change in gene expression profiles between immature DC (red), mature DC (green), tolDC (blue), or alternatively-activated tolerogenic DC (AADC, purple) in GSE52894. Each dot presents a sample, and each color represents a DC phenotype. (B) Heatmap representation of the top 20 differentially expressed genes (DEG) by tolDC. DEG were arranged by hierarchical clustering on the vertical axis. Datasets, also clustered by hierarchical clustering, are displayed on the horizontal axis. The p-value yielded from each study were converted to z-scores and plotted. (C) KEGG and (D) Gene Set Enrichment analyses. Each point on the dot plot represents the number of genes involved in the relevant pathway. The gene ratio is the proportion of DEG versus genes not differentially expressed. Each point was colored to represent the adjusted p-value using the Benjamini-Hochberg method.