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. 2021 Oct 20;12:733231. doi: 10.3389/fimmu.2021.733231

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Copyright © 2021 Robertson, Li, Kim, Rhodes, Harman, Patrick and Rogers

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TolDC gene set is overexpressed in liver-resident DC. (A) UMAP plot displaying the clustering of harmony integrated scRNAseq samples. (B) UMAP plot of liver datasets annotated by cell type. (C) Dot plot displaying up- and down-regulated tolDC gene expression markers enriched within cell clusters. (D) UMAP plot demonstrating a joint density analysis of upregulated genes from the tolDC gene set. (E) Boxplot displaying the expression of the tolDC gene set across tissue-resident and circulating DC. ****p < 0.0001.