Skip to main content
. 2021 Oct 20;12:733231. doi: 10.3389/fimmu.2021.733231

Figure 6.

Figure 6

Generating a mature DC transcriptome. (A) Heatmap representation of the top 52 DEG within the mature DC phenotype. (B) KEGG and (C) Gene Set Enrichment Analyses. (D) Mature DC gene-set expression in myeloid cell subsets isolated from epithelial tissues. (E) Comparison of tolDC and mature DC gene signatures in peripheral blood immune cell subsets. (F) Boxplot displaying the expression of genes critical to mature DC across DC in liver, kidney and PBMC. (G) Comparison of tolDC and mature DC gene set expression in liver, kidney and PBMC. (H) Mononuclear phagocytes from epithelial and subepithelial tissues were isolated and classified as DC or macrophage. The average expression of the mature DC gene signature was plotted between cells. A two-sample t-test was performed to determine statistically significant differences in base mean expression of the mature DC gene set across MNP. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.