TABLE 1.
Study characteristics of the 12 eligible publications.
| Publication Year | Database pull | Age group (Years) | Study setting/region | Initial size (N) | Male composition (%) | Composition | African-ancestry size (n) | African-ancestry Composition | Ethnicity group | Africans ancestry only (%) | Meta-analysis | Consortium | References |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2009 | GWAS Catalog; PM; PMC; Scopus; WoS | NA | United States | 1,017 | 41.2 | 509 AA cases, 508 AA controls | 1,017 | 509 AA cases, 508 AA controls | AA | 100 | No | HUFS | Adeyemo et al. (2009) |
| 2011 | GWAS Catalog; PM; PMC; Scopus; WoS | >18 | United States | 7473 | 39.7 | 7,473 AA | 7473 | 7,473 AA | AA | 100 | Yes | CARe (1a) | Fox et al. (2011) |
| 2013 | GWAS Catalog; PM; PMC; Scopus; WoS | ≥ 20 | United States; Nigera | 29378 | 27.1 | 28,190 AA, 1,188 Nigerian | 29378 | 28,190 AA, 1,188 Nigerian | AA; African-Ancestry (Nigerian) | 100 | Yes | COGENT (2a) | Franceschini et al. (2013) |
| 2019 | GWAS Catalog; PM | ≥ 18 | NR; United Kingdom | 4,59,777 | 91.5 | MVP (N = 318,891): whites (N = 5,265), blacks (N = 4,671), Asians (N = 3,936) and Hispanics (N = 1,838); United Kingdom Biobank: 140,886 empirically classified white | 4671 | 4,671 Blacks | African-ancestry | 1 | Yes | # MVP and UKB | Giri et al. (2019) |
| 2019 | GWAS Catalog; WoS | >18 | Uganda, Africa | 14126 | — | 14,126 African-ancestry | 14126 | 14,126 African-ancestry | African | 100 | Yes | UGR | Gurdasani et al. (2019) |
| 2017 | GWAS Catalog; Scopus; WoS | > 60.9 | United States | 99785 | 40.5 | Non-Hispanic whites (81%; 80,792), Latinos (8%; 8,231), East Asians (7%; 7,243), AAs (3%; 3,058), and South Asians (1%; 461) | 3058 | 3,058 AA | AA | 3 | Yes | * GERA | Hoffmann et al. (2017) |
| 2011 | GWAS Catalog; PM; PMC; Scopus; WoS | >18 | United States | 7917 | 39.7 | 4,069 AA cases, 3,848 AA controls; CARe; ARIC (N = 3,269), CARDIA (N = 1,209), CFS (N = 704), JHS (N = 2,200), and MESA (N = 1,737) | 7917 | 4,069 AA cases, 3,848 AA controls | AA | 100 | Yes | CARe (1b) | Lettre et al. (2011) |
| 2017 | GWAS Catalog; PM; PMC; Scopus; WoS | NA | United States; NR | 31968 | 30.3 | 31,968 of African-ancestry from 19 AA Cohorts and 2 African cohorts | 31968 | 31,968 African-ancestry from 19 AA Cohorts and 2 African cohorts | African ancestry | 100 | Yes | 21 Previous GWASs | Liang et al. (2017) |
| 2019 | GWAS Catalog; PM; PMC; Scopus; WoS | 10 to 11 | Uganda, Africa | 815 | 51.1 | 815 African-ancestry early adolescents | 815 | 815 African-ancestry early adolescents | African | 100 | No | EMaBS | Lule et al. (2019) |
| 2020 | GWAS Catalog | NA | United States | 1,520 | 39.1 | 281 AA or Afro-Caribbean, 598 Hispanic or Latin American, 125 East Asian, 516 Europeanls | 281 | 281 AA | AA | 18 | Yes | #GENNID | Willems et al. (2020) |
| 2019 | GWAS Catalog | NA | United States | 49839 | — | 49,839 non-European; 11,863 AA cases, 8,663 Hispanic/Latino cases, 3,102 Asian ancestry cases, 2,645 Native Hawaiian ancestry cases, 342 Native American ancestry cases, 508 cases, 5,289 AA controls, 13,273 Hispanic/Latino controls, 1,561 Asian ancestry controls, 1,060 Native Hawaiian ancestry controls, 293 Native American ancestry controls, 542 controls | 17152 | 11,863 AA cases,5,289AA controls | AA | 34 | Yes | *PAGE | Wojcik et al. (2019) |
| 2015 | PM; PMC; Scopus; WoS | ≥ 20 | United States; Nigera | 29378 | — | 28,190 AA, 1,188 Nigerian 3000 total used | 29378 | 28,190 AA, 1,188 Nigerian; 3000 total used | AA; African Ancestry (Nigerian) | 100 | Yes | COGENT (2b) | Zhu et al. (2015) |
Paper and population Characteristics of the 12 eligible publications. *Only African ancestry reported in this review (100% African ancestry), #Not 100% African ancestry. (a) Primary study (b) Secondary study. Red = Studies excluded when reporting genetic associations. Cohorts: AADM (Africa America Diabetes Mellitus Study), ARIC (Atherosclerosis Risk in Communities), CARDIA (Coronary Artery Risk Development in Young Adults), CARe (Candidate Gene Association Resource), CFS (Cleveland Family Study), CHS (Cardiovascular Health Study), COGENT (Continental Origins and Genetic Epidemiology Network), DCS (Diabetes Case-control Study), DDS (Durban Diabetes Study), EMaBS (Entebbe Mother and Baby Study), GENNID (GENetics of Noninsulin dependent Diabetes Mellitus), GERA (Genetic Epidemiology Research on Adult Health and Aging), GPC (General Population Cohort), HRC (Haplotype Reference Consortium), HUFS (Howard University Family Study), JHS (Jackson Heart Study).