TABLE 6.
Potential unique African-ancestry GW associations signals for 10 studies, based on 100% African-ancestry.
| No | Chr | SNP | Position | Reported Gene | Distance to gene (kb) | Type | EA | RA | EAF | Associated Traits | Reported Build | EuA | African-ancestry | Higher freq |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | rs556271823 | 210033781 | — | — | — | a | at | 0.06 | PP | GRCh37 | 0.1214 | 0.0483 | EuA |
| 2 | 2 | rs5743185 | 190446083 | PMS1 | 0 | Intronic | T | NA | 0.1418 | SBP | GRCh36 | 0.0696 | 0.0182 | EuA |
| 3 | 3 | rs114821199a | 40965875 | — | — | — | a | g | 0.01 | PP | GRCh37 | 0.0002 | 0.0145 | African-ancestry |
| 4 | 3 | rs147428270b | 41868721 | — | — | — | t | c | 0.63 | BP Multi-trait analysis | GRCh37 | 0.0759 | 0.6448 | African-ancestry |
| 5 | 6 | rs76987554a,b | 134080855 | — | — | — | t | c | 0.09 | SBP; BP Multi-trait analysis | GRCh37 | 0.0003 | 0.0910 | African-ancestry |
| 6 | 6 | rs79030490a,b | 134087689 | — | — | — | a | c | 0.09 | SBP; BP Multi-trait analysis | GRCh37 | 0.0003 | 0.0931 | African-ancestry |
| 7 | 7 | rs10279895a,b | 27328210 | — | — | — | a | g | 0.90 | HTN; BP Multi-trait analysis | GRCh37 | 0.0001 | 0.09283 | African-ancestry |
| 8 | 7 | rs115476423b | 149199964 | — | — | — | c | g | 0.94 | BP Multi-trait analysis | GRCh37 | 6.485E-05 | 0.0544 | African-ancestry |
| 9 | 8 | rs2446849 | 95172673 | CDH17 | — | — | T | - | 0.80 | BP Multi-trait analysis | GRCh36 | 0.9581 | 0.8059 | EuA |
| 10 | 8 | rs7006531a,b | 95110744 | — | — | — | a | g | 0.85 | PP; BP Multi-trait analysis | GRCh37 | 0.0006 | 0.1497 | African-ancestry |
| 11 | 8 | rs78192203a | 142375073 | — | — | — | a | t | 0.20 | DBP | GRCh37 | 0.0003 | 0.1961 | African-ancestry |
| 12 | 14 | rs11160059 | 91877083 | SLC24A4 | 0 | Intronic | A | NA | 0.1782 | SBP | GRCh36 | 1.0000 | 0.9288 | EuA |
Ranked by chromosome number for: (a) SBP. (b) DBP. (c) PP. (d) HTN. (e) BP Multi-trait analyses. Consisting of only GW associations (p < 5E-8). Chr: Chromosome, EA: Effect allele, EAF: Effect allele frequency, EuA: European allele frequency (Average of Finnish and non-Finnish population).