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. 2021 Oct 20;12:717570. doi: 10.3389/fphar.2021.717570

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Copyright © 2021 Kwon, Lee, Lee, Kim and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Funnel plots of (A) FEV1 (%) and (B) TER based on clinical symptoms. AECOPD, acute exacerbations of chronic obstructive pulmonary disease; FEV1, forced expiratory volume in one second; TER, total effective rate.