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. 2021 Nov 2;7:43. doi: 10.1038/s41526-021-00172-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Bold horizontal bars represent the mean. DI effect from Pre to D4 AM on the 2 gr averaged (*p) is reported as “*p < 0.0x” and is plotted on top of the diagram. The change from D4 AM to D4 PM (with or without cuffs) are not significant for any parameter (p not reported). Pre was prior to dry immersion; D4 AM represents 4 days of dry immersion (morning prior to donning cuffs for the day for the cuff gr). D4 PM represent the data in the afternoon of day 4, after 10 h with cuff on, for the cuff gr.