Table 2.

PK–PD model parameters.

	LVF (4 µg/mL)		LVF+ Rh2 (1 μM)		LVF+ Rh2 (5 μM)		LVF+ Rh2 (10 μM)
	Mean	CV (%)	Mean	CV (%)	Mean	CV (%)	Mean	CV (%)
k	0.086	36	0.077	45	0.085	38	0.071	41
Fa (×10−3)	10.5	21	14.3	25	17.6*	31	21.4**	28
EC50	10.6	32	12.4	42	9.4	33	11.8	37
Emax	310	24	301	35	321	31	305	25

The significance is indicated by *P < 0.05, **P < 0.01, versus LVF single treatment group.