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. 2021 May 31;28(11):3036–3051. doi: 10.1038/s41418-021-00799-8

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Fig. 2 — A Representative images of Pten^+/+ and Pten^398A/398A MEF cells exposed or not (CTR) to 10 Gy of ionizing radiation, fixed at the indicated times post-IR, and immunostained for γH2AX, and 53BP1. DAPI was used to stain DNA. B Quantification of the number of γH2AX nuclear foci in MEF cells expressing PTEN WT or PTEN 398A. Nuclear foci in at least 100 nuclei were counted. (t test, ****denotes p < 0.0001. C Quantification of the number of 53BP1 nuclear foci in Pten^+/+ and Pten^398A/398A MEF cells. Mean and standard error of the mean are indicated for each transfection. Nuclear foci in at least 100 nuclei were counted. ****denotes p < 0.0001.