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. 2021 Feb 24;42(11):1769–1779. doi: 10.1038/s41401-021-00613-8

Fig. 1. Screening of NLRP3 inflammasome-targeting natural compounds derived from essential oils.

Fig. 1

a The working model of the screening system for NLRP3 inflammasome-targeting natural compounds. b–d iBMDMs pretreated with LPS were then treated with natural compounds (two doses of each compound, 0.5 and 1 mM) from essential oils (EOs) and nigericin (Nig) for 1 h, and the cells and supernatants were harvested for analysis of the expression of cleaved IL-1β and cleaved caspase-1 (Casp-1) by Western blotting (b, c). The gray values were analyzed by ImageJ software (d).