Figure 7.

The parenchyma of the olfactory bulb is spared from infection

(A–D) Confocal images of sagittal sections through an OB of COVID #16. The SSTR2A-IR signal labels leptomeninges, and the TUBB3-IR signal labels OSN axons and OB neurons. N puncta are not visible in the tiled confocal image (A), with the single asterisk indicating a position in this section (B), and double asterisks and triple asterisks positions in adjacent sections (C) and (D). N puncta occur within the side of pia mater abutting the OB (B). N puncta are dispersed over an area of the pia mater containing abundant nucleocapsid-IR signal (C). PECAM1 labels endothelial cells of a blood vessel cut obliquely, and S puncta occur within its lumen (D).

(E) Sagittal section through an OB of COVID #7. N puncta occur within a swath of the pia mater that is partially detached.

(F) Sagittal section through an OB of COVID #27. The pia mater contains densely packed M puncta. PECAM1 puncta occur in endothelial cells of a blood vessel within the pia mater and blood vessels within the OB.

(G) Section through the leptomeninges including the transition zone to dura mater of COVID #60 shows scattered N and S puncta.

DAPI served as nuclear stain. See also Figure S2.