Table 2.
List of the 71 gray matter regions of interest derived from multivariate pattern analysis, with predefined atlas-based regions of interest. Coordinates for region of interest centers of mass and peak voxels (where applicable) are provided in MNI152 standard coordinate space.
| Type and CLUSTER_ID | Voxels | Center of mass (MNIa) | Peak (MNI) | ATLAS ROIb | ||||||
|
|
|
|
x | y | z | x | y | z |
|
|
| Brain stem | ||||||||||
|
|
bs1_bstem | 33 | –1.2 | –29.3 | –45.6 | 0 | –30 | –46 | Brainstem gray matter | |
| Basal ganglia | ||||||||||
|
|
caud1_Rput | 126 | 20.1 | 27.7 | 4.8 | 24 | 18 | 4 | R putamen/globus pallidus | |
|
|
caud2_Rput1 | 108 | 29.3 | 7.1 | 1.8 | 34 | 4 | 6 | R middle insula/putamen | |
|
|
caud3_Rgp | 45 | 22.3 | –9.4 | –3.1 | 22 | –14 | –4 | R globus pallidus/thalamus/motor thalamus | |
|
|
caud4_Rput | 36 | 31.3 | –18.7 | 1.9 | 32 | –16 | 0 | R putamen | |
| Cerebellar | ||||||||||
|
|
cb1_Rlob9 | 364 | 4.2 | –61.5 | –45.7 | 12 | –62 | –54 | R cerebellum (VIII) lobule IX | |
|
|
cb2_Llob6 | 269 | –21.7 | –49.8 | –46.7 | –28 | –48 | –38 | L cerebellum (VI)/prob. WM | |
|
|
cb3_Rlob8b | 99 | 16.4 | –46.9 | –50.3 | 18 | –46 | –50 | R cerebellum (IX) lobule VIIIb | |
|
|
cb4_Rlob7b | 82 | 32 | –74.9 | –54.1 | 28 | –76 | –54 | R cerebellum (VII) lobule VIIb | |
|
|
cb5_Rcrus2 | 52 | 10.5 | –72.2 | –24.7 | 6 | –72 | –28 | R cerebellar crus 2/vermis | |
|
|
cb6_Lcrus2 | 39 | –48.7 | –56.8 | –42.6 | –56 | –56 | –44 | L cerebellar crus 2/lobule VIIa crus I | |
| Cingulate | ||||||||||
|
|
cing1_Rpcc | 426 | 11 | –47.4 | 20.8 | 10 | –48 | 18 | R precuneus/posterior cingulate/BA23v | |
|
|
cing2_Rmicg | 21 | 18.3 | –33.3 | 49.8 | 18 | –34 | 50 | R middle cingulate cortex/ventromedial BA5 | |
| Frontal | ||||||||||
|
|
f1_Lba9 | 408 | –3.1 | 48.3 | 45 | –12 | 54 | 42 | L superior frontal gyrus/mid BA9 | |
|
|
f10_Lba6r | 33 | –50.9 | 4.3 | 16.5 | –52 | 4 | 16 | L precentral gyrus/BA44/rostral BA6/caudoventrolateral BA6 | |
|
|
f11_Rba6ba8 | 28 | 18.9 | 31.7 | 60.1 | 20 | 32 | 62 | R superior frontal gyrus/superior BA6-BA8 transitional area | |
|
|
f12_Lba6ba8 | 27 | –31.1 | 4 | 59.8 | –30 | 4 | 60 | L middle frontal gyrus/inferior BA6-BA8 transitional area | |
|
|
f2_Rba10p | 271 | 18.1 | 57.5 | –13.3 | 24 | 62 | 2 | R posterior BA10/superior frontal gyrus | |
|
|
f3_Rba8v | 207 | 47.6 | 10.6 | 44.5 | 48 | 12 | 48 | R ventral BA8A/caudal middle frontal gyrus/IFJ | |
|
|
f4_Rba8dl | 163 | 28.7 | 18.5 | 49.2 | 28 | 20 | 54 | R middle frontal gyrus/dorsolateral BA8A | |
|
|
f5_Lba8dl | 133 | –20 | 30.5 | 50.2 | –20 | 30 | 48 | L dorsolateral BA8A/superior frontal gyrus | |
|
|
f6_Lsma | 124 | –15.2 | 7.9 | 53.7 | –10 | 12 | 50 | L SMA/supplementary and cingulate eye area/medial frontal gyrus | |
|
|
f7_Rba24d | 90 | 1.9 | –24.6 | 46.1 | 2 | –22 | 50 | R dorsal BA24/SMA/superiomedial BA4 | |
|
|
f8_Rba10d | 88 | –17.5 | 62.6 | 7.9 | –22 | 60 | 10 | L superior frontal gyrus/dorsal BA10/BA46/area Fp1 | |
|
|
f9_Lba44v | 81 | –53.4 | 17.9 | 2.8 | –54 | 18 | 4 | L ventral BA44/inferior frontal gyrus pars triangularis | |
| Medial temporal | ||||||||||
|
|
mtl1_Lphg1 | 137 | –15.7 | –46.5 | –10.4 | –16 | –42 | –10 | L parahippocampal area 1/subiculum/lingual gyrus/area TH | |
|
|
mtl2_Rphg | 89 | 27 | –35.9 | –13.4 | 28 | –44 | –6 | R parahippocampal gyrus/rostral lingual gyrus/ventromedial visual area 1 | |
|
|
mtl3_Renrc | 83 | 21.2 | –26.6 | –28.5 | 22 | –28 | –26 | R entorhinal cortex/presubiculum/caudal BA35/36 | |
|
|
mtl4_Rprc | 50 | 29.6 | –1.1 | –34.4 | 30 | –2 | –34 | R perirhinal/ectorhinal cortex/rostral BA36/BA35/parahippocampal gyrus | |
|
|
mtl5_Lamg | 34 | –25.4 | –4.1 | –21 | –24 | –4 | –16 | L piriform cortex/amygdala/laterobasal amygdala | |
|
|
mtl6_Lenrc | 33 | –19.2 | –9.4 | –33.7 | –22 | –8 | –34 | L entorhinal cortex/BA28/BA34/parahippocampal gyrus | |
|
|
mtl7_Rhc | 23 | 30.3 | –16.2 | –18 | 30 | –16 | –14 | R hippocampus/CA3 fields/CA3 fields | |
| Occipital/visual | ||||||||||
|
|
o1_Rba39rd | 287 | 34.7 | –69.8 | 41.6 | 36 | –72 | 38 | R intraparietal area1/rostro-dorsal BA39/middle occipital gyrus | |
|
|
o2_Llop | 208 | –16.2 | –101.6 | –2.1 | –14 | –106 | –8 | L lateral occipital pole | |
|
|
o3_Rv2v3d | 29 | 23.5 | –98.9 | 10.7 | 24 | –98 | 10 | R superior occipital gyrus/visual area V2/dorsal visual area V3 | |
|
|
o4_Lv2 | 25 | –24.9 | –50.5 | 0 | –24 | –50 | 0 | L precuneus/prostriate area/lingual gyrus/visual area V2 | |
|
|
o5_Rba37mv | 20 | 22.3 | –42.3 | –17.2 | 22 | –44 | –18 | R ventral visual complex/area FG3/medioventral BA37 | |
| Opercular | ||||||||||
|
|
op1_Rro | 60 | 53.9 | 2.4 | 2.9 | 54 | 4 | 6 | R rolandic operculum/rostral BA6/BA43 | |
| Orbitofrontal | ||||||||||
|
|
orb1_Rba11 | 208 | 18.7 | 18.5 | –22.8 | 20 | 30 | –16 | R superior orbital gyrus/lateral BA11/area Fo3 | |
|
|
orb2_Lba10r14m | 94 | –5.3 | 41.3 | –12.7 | –6 | 44 | –16 | L rostral BA10/medial BA14/gyrus rectus | |
|
|
orb3_Rifgpo | 89 | 32.2 | 22.9 | –31.4 | 32 | 22 | –26 | R inferior frontal gyrus pars orbitalis/superior BA47/lateral BA11/area Fo3 | |
|
|
orb4_L47l | 76 | –49.5 | 29.6 | –5.9 | –46 | 28 | –6 | L lateral BA47/inferior frontal gyrus pars orbitalis | |
|
|
orb5_Rba10v | 49 | 4.2 | 59.6 | –11.3 | 6 | 60 | –10 | R ventral BA10/medial BA11/middle orbital gyrus | |
|
|
orb6_Lpofc | 36 | –14 | 14.1 | –14.4 | –14 | 14 | –14 | L gyrus rectus/area Fo2/posterior orbitofrontal complex/subcallosal gyrus | |
|
|
orb7_Lba11l | 34 | –20.1 | 32.1 | –18.8 | –18 | 34 | –22 | L superior orbital gyrus/area Fo3/lateral BA11 | |
|
|
orb8_Rofc | 25 | 2.1 | 16.1 | –21.7 | 2 | 16 | –22 | R orbitofrontal cortex/area Fo2 | |
|
|
orb9_Rba14m | 20 | 4.6 | 28.5 | –13.2 | 4 | 30 | –14 | R middle orbital gyrus/area s32/area 25/medial BA14 | |
| Prefrontal | ||||||||||
|
|
pfc1_Lba9pv | 50 | –37.5 | 33.8 | 22 | –40 | 28 | 26 | L posterior ventral BA9/BA46 | |
|
|
pfc2_Lba9av | 40 | –38.1 | 55.2 | 1.6 | –38 | 54 | 0 | L anteroventral BA9/46/rostral BA47 | |
| Parietal | ||||||||||
|
|
pl1_Lipl | 280 | –35 | –67.6 | 25.1 | –36 | –68 | 24 | L middle occipital gyrus/inferior parietal lobule/rostro-ventral BA39 | |
|
|
pl2_Lba7m | 233 | –2.9 | –53.5 | 58.1 | –6 | –52 | 66 | L medial BA7A/medial BA5 | |
|
|
pl3_Lba7m5ml | 190 | 44.6 | 20.4 | 10.3 | 46 | 16 | 6 | L medial BA7A/mediolateral BA5 | |
|
|
pl4_Lpos2 | 114 | –4.2 | –65.9 | 42.6 | –2 | –70 | 44 | L parieto-occipital sulcus area 2/medial BA7/precuneus | |
|
|
pl5_Rpos2 | 32 | 16.9 | –59.5 | 28.2 | 20 | –60 | 26 | R precuneus/parieto-occipital sulcus area 2 | |
| Temporal | ||||||||||
|
|
t1_Lffc | 95 | –46.6 | –56.9 | –18.9 | –44 | –60 | –16 | L fusiform gyrus/fusiform face complex/lateroventral BA37/area FG2 | |
|
|
t10_Ravsts | 31 | 56.3 | –7.2 | –21.6 | 56 | –6 | –20 | R anteroventral superior temporal sulcus/middle temporal gyrus | |
|
|
t11_Laud5 | 31 | –61.5 | –0.3 | –8.7 | –64 | –4 | –4 | L superior temporal gyrus/area TE3/auditory 5 complex | |
|
|
t12_Rba38l | 28 | 47.2 | 21.4 | –26.3 | 48 | 22 | –26 | R temporopolar cortex/lateral BA38/dorsal area TG | |
|
|
t13_Lpiri | 6 | –41.7 | 6 | –10.7 | –40 | 4 | –12 | CLUSTER5/L piriform cortex/insula/posterior insula area 2 | |
|
|
t14_Lba37vl | 3 | –48.7 | –64 | –3.3 | –48 | –64 | –4 | CLUSTER10/middle temporal gyrus/area PH/ventrolateral BA37 | |
|
|
t2_Lba38l | 68 | –35.3 | 4 | –23.2 | –38 | 6 | –20 | L dorsal area TG/lateral BA38/temporopolar cortex | |
|
|
t3_Rba22 | 64 | 66.9 | –17.3 | 0 | 66 | –14 | 0 | R auditory 4 complex/area TE3/caudal BA22 | |
|
|
t4_Lba20il | 62 | –54.8 | –11.9 | –34.2 | –56 | –12 | –32 | L anterior area TE2/inferolateral BA20/inferior temporal gyrus | |
|
|
t5_Lba22c | 60 | –65.2 | –46.7 | 11.8 | –68 | –48 | 12 | L superior temporal visual area/caudal BA22 | |
|
|
t6_Rins | 45 | 34.2 | –16.7 | 23.4 | 34 | –14 | 22 | R insula/area OP2-3/VS | |
|
|
t7_Lpins2 | 37 | –35.4 | –6.4 | –6.5 | –36 | –8 | –4 | L posterior insular area 2/circular insula | |
|
|
t8_Lba38m | 36 | –45.8 | 24 | –25.4 | –44 | 26 | –26 | L temporopolar cortex/dorsal area TG/medial BA38 | |
|
|
t9_Raud5 | 33 | 65.1 | –38.6 | 5.5 | 66 | –38 | 6 | R middle temporal gyrus/auditory 5 complex/ventral superior temporal sulcus | |
| Thalamic | ||||||||||
|
|
th1_Lpfthal | 82 | –5.7 | –14.4 | –3.5 | –6 | –14 | –2 | L thalamus/thalamic area IPF/prefrontal-directed thalamus | |
|
|
th2_Rpmthal | 72 | 15.5 | –18.6 | 4.9 | 16 | –18 | 6 | R thalamus/premotor-directed thalamus | |
| Predefined | ||||||||||
|
|
medial PFCc (DMNd) | —e | 1 | 55 | –3 | N/Af | N/A | N/A | medial prefrontal cortex, default mode network | |
|
|
L lateral parietal (DMN) | — | –39 | –77 | 33 | N/A | N/A | N/A | L lateral parietal cortex/von Economo PG, default mode network | |
|
|
R lateral parietal (DMN) | — | 47 | –67 | 29 | N/A | N/A | N/A | R lateral parietal cortex/von Economo PG, default mode network | |
|
|
posterior cingulate (DMN) | — | 1 | –61 | 38 | N/A | N/A | N/A | posterior cingulate cortex, default mode network | |
|
|
L lateral sensorimotor | — | –55 | –12 | 29 | N/A | N/A | N/A | L lateral sensorimotor cortex | |
|
|
R lateral sensorimotor | — | 56 | –10 | 29 | N/A | N/A | N/A | R lateral sensorimotor cortex | |
|
|
superior sensorimotor | — | 0 | –31 | 67 | N/A | N/A | N/A | superior (mesial) sensorimotor cortex | |
|
|
medial visual | — | 2 | –79 | 12 | N/A | N/A | N/A | medial visual cortex/Brodmann 18/calcarine gyrus/visual area V1 | |
|
|
occipitopolar visual | — | 0 | –93 | –4 | N/A | N/A | N/A | occipitopolar visual cortex/Brodmann 17/calcarine gyrus | |
|
|
L lateral visual | — | –37 | –79 | 10 | N/A | N/A | N/A | L lateral visual cortex/visual area V4 | |
|
|
R lateral visual | — | 38 | –72 | 13 | N/A | N/A | N/A | R lateral visual cortex/visual area V4 | |
|
|
anterior cingulate (SNg) | — | 0 | 22 | 35 | N/A | N/A | N/A | anterior cingulate cortex, salience network | |
|
|
L anterior insula (SN) | — | –44 | 13 | 1 | N/A | N/A | N/A | L anterior insula, salience network | |
|
|
R anterior insula (SN) | — | 47 | 14 | 0 | N/A | N/A | N/A | R anterior insula, salience network | |
|
|
L rostral PFC (SN) | — | –32 | 45 | 27 | N/A | N/A | N/A | L rostral prefrontal cortex, salience network | |
|
|
R rostral PFC (SN) | — | 32 | 46 | 27 | N/A | N/A | N/A | R rostral prefrontal cortex, salience network | |
|
|
L supramarginal g. (SN) | — | –60 | –39 | 31 | N/A | N/A | N/A | L supramarginal gyrus/Brodmann 40, salience network | |
|
|
R supramarginal g. (SN) | — | 62 | –35 | 32 | N/A | N/A | N/A | R supramarginal gyrus/Brodmann 40, salience network | |
|
|
L FEF (DANh) | — | –27 | –9 | 64 | N/A | N/A | N/A | L frontal eye fields, dorsal attention network | |
|
|
R FEF (DAN) | — | 30 | –6 | 64 | N/A | N/A | N/A | R frontal eye fields, dorsal attention network | |
|
|
L inferior parietal s. (DAN) | — | –39 | –43 | 52 | N/A | N/A | N/A | L inferior parietal sulcus, dorsal attention network | |
|
|
R inferior parietal s. (DAN) | — | 39 | –42 | 54 | N/A | N/A | N/A | R inferior parietal sulcus, dorsal attention network | |
|
|
L lateral PFC (FPNi) | — | –43 | 33 | 28 | N/A | N/A | N/A | L lateral prefrontal cortex/Brodmann 9/46, frontopolar network | |
|
|
L posterior parietal cortex (FPN) | — | –46 | –58 | 49 | N/A | N/A | N/A | L posterior parietal cortex/von Economo PFm, frontopolar network | |
|
|
R lateral PFC (FPN) | — | 41 | 38 | 30 | N/A | N/A | N/A | R lateral prefrontal cortex/Brodmann 9/46, frontopolar network | |
|
|
R posterior parietal cortex (FPN) | — | 52 | –52 | 45 | N/A | N/A | N/A | R posterior parietal cortex/von Economo PFm, frontopolar network | |
|
|
L inferior frontal language area | — | –51 | 26 | 2 | N/A | N/A | N/A | L inferior frontal gyrus | |
|
|
R inferior frontal language area | — | 54 | 28 | 1 | N/A | N/A | N/A | R inferior frontal gyrus | |
|
|
L posterior STGj language area | — | –57 | –47 | 15 | N/A | N/A | N/A | L posterior superior temporal gyrus | |
|
|
R posterior STG language area | — | 59 | –42 | 13 | N/A | N/A | N/A | R posterior superior temporal gyrus | |
|
|
Anterior cerebellum | — | 0 | –63 | –30 | N/A | N/A | N/A | Anterior cerebellum | |
|
|
Posterior cerebellum | — | 0 | –79 | –32 | N/A | N/A | N/A | Posterior cerebellum | |
aMNI: Montreal Neurological Institute stereotactic coordinate system.
bROI: regions of interest.
cPFC: prefrontal cortex.
dDMN: default mode network.
eNot available (for predefined ROIs, subject signals for correlation analyses were derived from the average signal over the entire region and cluster sizes are not available).
fN/A: not applicable (for predefined ROIs, subject signals for correlation analyses were derived from the average signal over the entire region and peak voxel locations are not available).
gSN: salience network.
hDAN: dorsal attention network.
iFPN: frontopolar network.
jSTG: superior temporal gyrus.