Fig. 2.

Phylogenetic network of 169 HPVI6 viral genomes belonging to two distinct lineages and three sub-lineages. Each circle represents a haplotype and the diameter is proportional to the number of genomes belonging to each haplotype. A total of 97 bi-allelic variations were used to construct the haplotypes. Each notch on the horizontal lines indicate a differentiating variant. The colors indicate the sub-lineage Al; SCC (blue) and non malignant 〈green〉. LCR:7577T variant and the non-synonymous variants E5:3979C,A4042G, E6:350G are labeled. All the lineage D haplotypes except for one viral isolate (encircled in red) harbored both the non-synonymous variants. The smaller red circles are the median vectors and the arrow indicates the reference viral haplotype NC_001526.4.