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Solution behavior of an ASD containing two drugs, A and B, in buffer and in FaSSIF, assuming both drugs are miscible and neutral at the solution pH. The amount of the molecularly dissolved drug in the aqueous media exceeds the amorphous solubility of both drugs, leading to phase separation and precipitation of AB (as a colloidal precipitate). Drugs A and B are solubilized at different levels by FaSSIF leading to a higher solubility increase of drug A compared to drug B in FaSSIF.
