Table 5. Relative Amount of Detected Degradation Products of PZQ and PZQ/CD Complexes Formed Following Storage under Accelerated Solid Stress Conditions (40 °C and 75% RH for 3 Months)a.
| % peak area |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| analyte | time | RRT 0.57 | RRT 0.60 | RRT 0.77 | RRT 0.90 | RRT 0.95 | RRT 1.10 | RRT 1.14 | RRT 1.17 | RRT 1.23 | PZQ |
| PZQ | T0 | 0.14 | 1.83 | 0.14 | 97.90 | ||||||
| 2 weeks | 0.14 | 2.32 | 0.26 | 97.28 | |||||||
| 1 month | 2.31 | 0.17 | 97.52 | ||||||||
| 2 months | 2.28 | 97.72 | |||||||||
| 3 months | 2.18 | 97.82 | |||||||||
| PZQ/HPβCD | T0 | 1.05 | 1.60 | 1.21 | 92.86 | ||||||
| 2 weeks | 1.72 | 1.10 | 1.18 | 1.14 | 93.51 | ||||||
| 1 month | 4.35 | 2.99 | 0.73 | 0.47 | 2.21 | 4.46 | 81.81 | ||||
| 2 months | 6.29 | 0.58 | 2.07 | 3.12 | 1.13 | 5.37 | 5.10 | 74.25 | |||
| 3 months | 8.88 | 2.73 | 3.22 | 2.99 | 8.87 | 8.94 | 62.54 | ||||
| PZQ/RMβCD | T0 | 1.47 | 98.53 | ||||||||
| 2 weeks | 0.30 | 0.35 | 0.16 | 1.51 | 97.68 | ||||||
| 1 month | 0.83 | 1.39 | 0.41 | 96.52 | |||||||
| 2 months | 1.11 | 0.94 | 0.97 | 1.38 | 94.49 | ||||||
| 3 months | 0.96 | 0.83 | 1.48 | 0.62 | 96.11 | ||||||
| PZQ/SBEβCD | T0 | 1.44 | 96.97 | ||||||||
| 2 weeks | 1.03 | 0.97 | 0.45 | 1.51 | 2.10 | 93.94 | |||||
| 1 month | 2.21 | 1.22 | 1.35 | 94.07 | |||||||
| 2 months | 2.33 | 4.61 | 93.06 | ||||||||
| 3 months | 0.83 | 5.03 | 94.14 | ||||||||
RRT = RT (degradation product)/RT(PZQ).