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. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: J Med Chem. 2021 May 4;64(9):5874–5885. doi: 10.1021/acs.jmedchem.1c00038

Figure 3.

Figure 3.

MR imaging of CFA-induced subcutaneous inflammation. (a–d) Imaging from precontrast and at ~60 min for heMAMP, DOTA-Gd, and MPO-Gd in wild-type mice and heMAMP in Mpo−/− mouse. (e) Normalized contrast-to-noise ratio (CNR) of the MR imaging over a time period of ~60 min (all at 0.3 mmol/kg dosage, except for 0.1 mmol/kg of heMAMP for wild-type mice as labeled). (f) Activation ratio of the MR imaging over a time period of ~60 min demonstrated an approximately 2-fold higher activation ratio for heMAMP compared to that of MPO-Gd at ~60 min, both of which are much higher than DOTA-Gd, and that of Mpo−/− mouse (Δmouse CNRpost-contrast – CNRpre-contrast, n = 3 for each group).