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Stability of heMAMP: Transmetalation in the Presence of Zn2+ and Ca2+
| R1(t=72h)/R1(t=0) | t (min) for R1(t)/R1(t=0) = 0.8 | |||
|---|---|---|---|---|
| heMAMP | Zn2+ | >0.97 | Zn2+ | >5000 |
| Ca2+ | >0.96 | Ca2+ | >5000 | |
| MPO-Gd | Zn2+ | 0.76* | Zn2+ | 2866* |
| Ca2+ | 0.94 | Ca2+ | 4260 | |
heMAMP (1 mM) or MPO-Gd (1 mM) was incubated with ZnCl2 (2.5 mM) or CaCl2 (2.5 mM) in phosphate-buffered saline (PBS) for 95 h at 40 °C and T1 relaxation time was measured at different time points at 0.47 T (n = 3).
Taken from ref 17, other data are from this work.
