Table 3.
Binary logistic regression analysis of determinants associated with thrombocytopenia
| Variables | Platelet count < 100 × 109/La | The drop decrease of platelet count was ≥ 25%b | ||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | |
| Age (years) | 1.015 | 0.995–1.035 | 0.139 | 1.013 | 0.997–1.030 | 0.105 |
| Sex | 0.631 | 0.324–1.230 | 0.176 | 0.649 | 0.380–1.108 | 0.113 |
| CrCl, mL/min | ||||||
| ≥ 60 (reference) | 1.000 | – | – | 1.000 | – | – |
| ≥ 30, < 60 | 0.975 | 0.464–2.048 | 0.947 | 1.231 | 0.668–2.266 | 0.505 |
| < 30 | 1.876 | 0.864–4.071 | 0.112 | 1.550 | 0.766–3.135 | 0.223 |
| Baseline platelet count (109/L) | 0.992 | 0.988–0.995 | 0.000 | 1.001 | 0.999–1.004 | 0.201 |
| Linezolid therapy duration, days, | ||||||
| < 7 | 1.000 | – | – | 1.000 | – | – |
| ≥ 7, < 14 | 3.463 | 1.796–6.676 | 0.000 | 3.767 | 2.213–6.413 | 0.000 |
| ≥ 14 | 2.508 | 1.047–6.006 | 0.039 | 2.615 | 1.260–5.429 | 0.010 |
| Shockc | 2.091 | 1.127–3.880 | 0.019 | 1.907 | 1.132–3.213 | 0.015 |
CrCL creatinine clearance rate
Bold values show statistical significance of differences
aThrombocytopenia with platelet count < 100 × 109/L and a decrease in 25% or more from baseline of the platelet count
bThrombocytopenia due to a platelet count drop decrease of 25% or more from baseline
cShock patients require vasoactive medications