TABLE 1.
Case | Age of onset | Sex | Phenomenology of tics | Vocalizations | Suppressibility | Presence of premonitory urge | Presence of “tic attacks” | Unusual triggers | Other concurrent somatic manifestations | Pharmacological treatment and outcome* |
---|---|---|---|---|---|---|---|---|---|---|
1 | 16 yr | F | Dystonic (face); clonic (face, extremities); stereotypic (hands); complex motor with concomitant vocalization | Palilalia, short phrases, vowel sounds, sniffing, single words | No | No | Yes | Talking to other people | Dissociative symptoms of feeling like body parts were not her own, dyspnea, stuttering, transient confusion | Guanfacine 0.5 mg at bedtime; all symptoms resolved after 4 doses, discontinued without recurrence of symptoms |
2 | 14 yr | F | Dystonic (face, neck); clonic (extremities); stereotypic (hands); complex motor with concomitant vocalization | Whistling, coprolalia, short phrases, clicking, purring | No | No | Yes | Flashing lights, hearing whistling | Functional tremor | N/A |
3 | 13 yr | F | Dystonic (face); clonic (face, neck, extremities); stereotypic (hands); complex motor with concomitant vocalization | Short phrases, clicking, single words, squeaking | Yes** | Yes | Yes | Flashing lights, loud noises, the word “sound”, dampness of her hair, 7 pm every night | None |
Fluphenazine 0.5 mg every morning and 1 mg at bedtime, led to daytime somnolence, felt as though movements were easier to suppress. Diazepam 2 mg as needed, allowed for movements to be suppressed, discontinued |
4 | 14 yr | F | Dystonic (neck); clonic (extremities); stereotypic (hands) | Single words, blowing raspberries, squeaking | No | Yes | Yes | Presence of other people | Functional stereotypy, functional tremor | Pimozide 2 mg daily; no improvement, led to daytime somnolence, discontinued |
5 | 14 yr | F | Dystonic (extremities) Clonic (face, extremities) Stereotypic (hands) | Short phrases, coprolalia, whistling | No | No | Yes | None | Functional tremor | N/A |
6 | 14 yr | F | Dystonic (face, neck, extremities); clonic (face, neck, extremities); stereotypic (hands); complex motor with concomitant vocalization | Grunting, vowel sounds, clicking, short phrases, whistling | No | No | Yes | Loud noises, loud footsteps, hearing whistling sounds, extremes of temperature | None | Clonidine 0.1 mg twice daily; no improvement led to daytime somnolence, discontinued |
Abbreviations: F, Female.
Pharmacological treatments were administered by providers before our evaluation.
Movements and sounds were suppressible following initiation of pharmacologic treatment.