Skip to main content
. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: J Inherit Metab Dis. 2019 Mar 5;42(3):509–518. doi: 10.1002/jimd.12057

FIGURE 1.

FIGURE 1

A, Results from 625 WBC analyses: Normal LAL activity (cut-off >25 pmol/min/mg protein) (n = 521, average = 62.92 ± 3.98 pmol/min/mg protein, 95% confidence interval), reduced LAL activity (cut-off >12 and < 25 pmol/min/mg protein) (n = 67, average = 19.32 ± 0.86 pmol/min/mg protein, 95% confidence interval), and deficient LAL activity (cut-off <12 pmol/min/mg protein) (n = 37, average = 5.9 ± 1.42 pmol/min/mg protein, 95% confidence interval). A significant distribution of normal and affected individuals emerged. t test comparing two by two categories and anova showed the three groups different with high statistical significance P < 0.0001. B, Correlation between the age at diagnosis and LAL activity in the cohort. The Pearson’s r resulted 0.46 (95% confidence interval 0.1591 to 0.6819) and P < 0.005 (one-tailed). A moderate linear relationship emerged suggesting higher LAL enzyme activity does correlate with moderate power with a later age of diagnosis. Dots represent deficient LAL activities (0–12 pmol/min/mg protein) of 37 patients and dotted lines enclose the 95% confidence interval values