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. 2021 Oct 22;6(20):e151527. doi: 10.1172/jci.insight.151527

Figure 3. Procoagulant tissue signature of COVID-19 lung endothelium.

Figure 3

Lung specimens were obtained during limited autopsy immediately after death in patients who died from COVID-19 (n = 5). Control samples (n = 4) were obtained from tumor-free margins of lung tumor resections and processed in identical fashion regarding timing and method of fixation. Lung specimens from patients with COVID-19 demonstrated (A) an increase in the prothrombotic endothelial protein vWF and (B and C) a loss of the antithrombotic factors thrombomodulin (THBD) and EPCR. In each tissue section, 2 images were obtained and mean fluorescence intensity was analyzed for each tile-scanned image and normalized to background intensity. Scale bar: 100 μm. For graphs, mean is represented by the bar with each dot as a replicate; error bars indicate SD. Significance was determined by a 2-tailed Mann-Whitney test, **P < 0.01, ****P < 0.0001.